Chapter #7 : Gene therapy has introduced a new way to treat cancer.

Chapter #7 : Gene therapy has introduced a new way to treat cancer.

            When someone have viral infection, the immune system can work very hard to kill the infection. Unfortunately, the immune system can't recognize cancer cells, which makes it ineffective to defeat tumors. Steve Rosenberg from National Cancer Institute was the first scientist to use gene therapy approach to treat patients with cancer. He successfully manipulated the human immune cells to give it the ability to recognize and kill cancer tumors. The author of the article, " Gene Therapy May Bring Cancer Killing-Cells" explains that Dr. Rosenberg was able to transfer a genetically modified T-cells to patients with cancer and succeed in treating  several patients with melanoma. The author mentioned that Dr. Rosenberg explained that cancer cells have their own way to evade the immune response, and by altering T-cells using gene therapy, we can make those cells able to recognize and kill tumors. The only problem that the article discussed regarding using this gene therapy approach is the high costs of this kind of research.

            Personally, I think that the author poorly explained how exactly the T-cells were modified to make it able to recognize the tumor. He also did not mention if this gene therapy performed in T-cells will be passed through offspring or not. If I have cancer, and I am going to pay for gene therapy treatment, I really want my second generation to benefit from this treatment. Rather than sensationalizing people who have cancer  and the public to be more interested in the research, the author could have done a better job giving accurate data on number successful and frailer cases in the study. 

Resources:

http://www.npr.org/templates/story/story.php?storyId=5744500

http://images.1233.tw/somatic-gene-therapy/ 

Chapter # 6: Gene Therapy FAQ

Chapter #6:

Gene Therapy FAQ

1.      What is gene therapy?

Gene Therapy is a way to treat diseases by correcting the faulty gene. A new functional gene is replaced by the faulty or non-functional one.

2.      How many types of gene therapy are there?

There are two types of gene therapy, somatic cell gene therapy, where a normal gene introduced to the body cells like skin, blood, and bone marrow. There is also germline gene therapy, where the new functional gene is introduced to germ cells (egg and sperms).

3.      How does gene therapy work?

Scientists use viruses as the delivery vectors to carry on the desired gene and deliver it to the targeted cell.The DNA for the desired gene is inserted into the genetic material of the virus and then the virus itself is inserted into the human cell. .

4.      Can the virus that is used to carry the corrected gene harm my body?

The viruses that are used to carry the desired genes are engineered so they cannot reproduce inside our body, which minimize any bad effects.

5.      Is there any successful cases of gene therapy?  

There are many successful cases in gene therapy including Heredity blindness, Hemophilia, Fat Metabolism disorder, Cancer, Parkinson’s disease.

6.      Is gene therapy available to treat my disorder?

Gene therapy is still in clinical trials, the FDA has not approved to perform gene therapy in humans yet.

Resources: 

http://learn.genetics.utah.edu/content/genetherapy/gtsuccess/

http://ghr.nlm.nih.gov/handbook/therapy

http://www.geogene.com/gene-therapy.html

http://learn.genetics.utah.edu/content/genetherapy/gtchallenges/

http://discovermagazine.com/2009/sep/02-second-coming-of-gene-therapy

https://www.ndsu.edu/pubweb/~mcclean/plsc431/students/bergeson.htm

http://blog.supercoder.com/icd-10-2/cms-offers-assistance-in-transitioning-to-icd-10/

Chapter Five: Arguments For and Against Gene Therapy

Chapter Five: Arguments For and Against Gene Therapy

            While some people think that gene therapy is a great discovery that will cure many diseases, others think it is risky with unknown long terms effects and we should avoid it to avoid any bad consequences. The public debate around the use of gene therapy begin when clinical trials of gene therapy started long time ago. Since gene therapy deals with changing the genetic makeup of the body, there are many ethical and social issues surround the use of gene therapy. 

            In one hand there are many people in the public who holds thoughts supporting the use of gene therapy. One of the strongest public arguments for gene therapy is that it will end suffering from many diseases by finding treatments for these disease. For instance, when a genetic disease is inherited within a family, the family individuals can undergo genetic screening to know if they carry the faulty gene for that disease.  If they do so, they can undergo gene therapy and cure that disease without suffering. Even if this looks a great opportunity to end suffering from certain disease, there are some ethical issues surrounding genetic testing and gene screening. Bioethics think that a parent who test the genetic composition of their fetus might want to abort that child if he tests positive for certain disease. This will increase the rate of apportion. Also, other bioethics think that the high costs of gene therapy may makes it available only for the rich people to use. Another argument for gene therapy, is that it targets the cause of the disease not the symptoms, which makes it the best among other general practices. 

            On the other hands, Some people argue against the use of gene therapy. Since gene therapy deals with changing the genetic makeup of the body, there are many people think that using gene therapy scientists are trying to "play God" by manipulating the genetic composition of the human being. They think that even though it can produce good effects like eliminating diseases, it can also produce devastating effects because we do not know the complexity of the human being enough to play with it and manipulate it. Another argument against gene therapy is the fear that some might use it to enhance physical traits like beauty and intelligence, which will give some people more life opportunities than others. 

Recourses: 

https://www.ndsu.edu/pubweb/~mcclean/plsc431/students99/wharam.htm

https://www.musc.edu/humanvalues/pdf/gene-therapy.pdf

http://ghr.nlm.nih.gov/handbook/therapy/ethics

http://thirdspacemedical.com/services/internal-anti-aging/restorative-medicine/diagnostics-and-testing/genetic-fit-test/

Chapter Four: Gene Therapy Regulations

            When we talk about changing the biological make up of an individual, that must be something very dangerous. Our genetic make up makes us what we are, so changing this genetic composition should be highly regulated to avoid the long term risks. Ross Laframboise in his article "Gene Therapy Regulations: A Proactive Approach", explains the importance of regulating gene therapy researches in order to minimize the risks. He mentions that there are two main organizations now regulating gene therapy researches including US Food and Drug Administration (FDA) which makes sure of the safety during researches, and  Recombinant DNA Advisory Committee (RAC) that is responsible of reviewing gene therapy protocols. Besides these two organizations, the author expresses the importance of the government regulation especially for germline gene therapy. Since germline gene therapy can affect the future generations, we need to take cautions on the specific genetic composition that we are going to change. The author also mentions that some organizations should be responsible of adopting the ethical issues regarding gene therapy to prevent any social problems. 

 

References: 

https://www.ndsu.edu/pubweb/~mcclean/plsc431/students/ross.htm

https://bigkingken.wordpress.com/2011/07/20/pain-relief-from-herpes-virus-not-a-typo/

Chapter Three: A Cure for Colorblindness Using Gene Therapy Approach

A Cure for Colorblindness Using Gene Therapy Approach.

​Using gene therapy approach, scientists at the university of Washington was successfully able to cure colorblindness in monkeys. The article "A cure for 'colorblindness' may be in sight" from the CNN news, explains that Maureen Neitz and Jay Neitz found that monkeys who suffer from color blindness are unable to differentiate between green and red color. Lookinginto their genes, they found that one of the genes that are responsible for encoding these two colors was missed. In fact, this what makes those monkey see things that are green or red relatively similar. In order to cure the monkeys, scientists replaced a new gene to the retina using a weak virus to deliver the gene. Finally, they test the monkeys and announced that their therapy was successful. Although this gene therapy was not tested in humans and the FDA did not give their permission for that, scientists gave those people suffering from colorblindness a hope for cure.  

​Even though the story adequately covers the most important steps in using gene therapy approach to treat diseases including how to find the faulty gene, how to deliver the corrected gene, and finally testing if the therapy actually worked, the story did not adequately covers the long term effectsof this gene therapy. One of the disadvantages of gene therapy is that the long term effects are not known. Therefore, scientists have to study the long term effects of their therapy before saying it worked on monkeys or is going to be working in humans. Another important point that the story did not mention is if this corrected gene will be passed to the second generation. If I am a colorblind person, I need to know if this therapy will affect my offspring or not before I decide to undergo this gene therapy. 

References:

https://www.youtube.com/watch?t=352&v=EgPMc90uXlU

http://www.pri.org/stories/2015-09-20/cure-colorblindness-may-be-sight

http://genetherapyinfo.webs.com/advantages-vs-disadvantages